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Literature summary for 2.7.1.153 extracted from

  • Gavard, J.; Hou, X.; Qu, Y.; Masedunskas, A.; Martin, D.; Weigert, R.; Li, X.; Gutkind, J.S.
    A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability (2009), Mol. Cell. Biol., 29, 2469-2480.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Application

Application Comment Organism
pharmacology the PI3Kgamma signaling pathway may represent a suitable target for the development of therapeutic strategies for human diseases characterized by vascular leakage Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
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 Mus musculus
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retina
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
CXCR2/phosphatidylinositol 3-kinase gamma
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 Mus musculus
CXCR2/phosphatidylinositol 3-kinase gamma
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function isozyme PI3Kgamma is involved in inteleukin-8-induced increase of endothelial monolayer permeability and is able to limit neovascularization and choroidal edema, as well as macrophage infiltration, therefore contributes to reduce laser-induced retinal damage Mus musculus
physiological function isozyme PI3Kgamma is involved in inteleukin-8-induced increase of endothelial monolayer permeability and is able to limit neovascularization and choroidal edema, as well as macrophage infiltration, therefore contributes to reduce laser-induced retinal damage Homo sapiens