Literature summary for 2.7.1.153 extracted from

Munugalavadla, V.; Vemula, S.; Sims, E.C.; Krishnan, S.; Chen, S.; Yan, J.; Li, H.; Niziolek, P.J.; Takemoto, C.; Robling, A.G.; Yang, F.C.; Kapur, R.
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration (2008), Mol. Cell. Biol., 28, 7182-7198.

Search for more literature for 2.7.1.153

Cloned(Commentary)

Cloned (Comment)	Organism
expression of p85 constructus from a retroviral vector	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	deficiency of PI3-K regulatory subunit p85alpha in vivo results in a significantly greater number of trabeculae and significantly lower spacing between trabeculae as well as increased bone mass in both males and females compared to their sex-matched wild-type controls. p85-/- osteoclast progenitors show impaired growth and differentiation, which is associated with reduced activation of Akt and mitogen-activated protein kinase Erk1/Erk2 in vitro, and a significant reduction in the ability of p85-/- osteoclasts to adhere to as well as to migrate via integrin alphanybeta3. Restoring the expression of the full-length form of p85alpha but not the version with a deletion of the Src homology-3 domain restores the maturation of p85-/- osteoclasts to wild-type levels, overview. Phenotypes, overview	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + phosphatidylinositol-4,5-bisphosphate	Homo sapiens	-	ADP + phosphatidylinositol-3,4,5-trisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone	-	Homo sapiens	-
osteoclast	osteoclasts express multiple regulatory subunits of class IA PI3-K, although the expression of the full-length form of p85alpha is most abundant	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + phosphatidylinositol-4,5-bisphosphate	-	Homo sapiens	ADP + phosphatidylinositol-3,4,5-trisphosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	regulatory p85alpha and p85beta subunits of class IA PI3-K share near identity in the functional domains in the C-terminus, including the amino-SH2 and the carboxy-SH2 domains, which are critical for mediating association with other SH2-containing proteins as well as binding to the p110 catalytic subunit	Homo sapiens

Synonyms

Synonyms	Comment	Organism
class IA phosphatidylinositol 3-kinase	-	Homo sapiens
PI3-K	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	SHIP downregulates PI3-K-initiated signals by dephosphorylating PI-3,4,5-triphosphate	Homo sapiens
physiological function	the p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration	Homo sapiens

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Release 2023.1 (January 2023)