Protein Variants | Comment | Organism |
---|---|---|
D910A | mice with an inactivating knock-in mutation in the p110delta isoform of PI3K, p110deltaD910A, generated on Leishmanina major resistant and susceptible genetic backgrounds. The mutant mice show severely impaired T cell responses, but the mutant mice also show more robust resistance to Leishmanina major infection manifested as significantly reduced lesion size and accelerated parasite clearance. Cells from p110D910A mice were significantly impaired in their ability to make cytokines, particularly IFN-gamma, interleukin-10, and TNF, phenotypes, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice, BALB/c mice, and CB-17/lcr-Prkdcscid/Crl, i.e. BALB/c SCID, mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
bone marrow cell | - |
Mus musculus | - |
femur | - |
Mus musculus | - |
L-929 cell | - |
Mus musculus | - |
leukocyte | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
tibia | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Mus musculus |