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Literature summary for 2.7.1.153 extracted from

  • Renner, O.; Blanco-Aparicio, C.; Grassow, M.; Canamero, M.; Leal, J.F.; Carnero, A.
    Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation (2008), Cancer Res., 68, 9643-9653.
    View publication on PubMed
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of phosphatidylinositol 3-kinase by membrane localization of subunit p110alpha Mus musculus
additional information activation of phosphatidylinositol 3-kinase by membrane localization of subunit p110alpha Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of different transgenic lines expressing myristoylated p110A protein under the control of the epithelial-specific mouse mammary tumor virus promoter, i.e. myrp110A transgenic mice. The membrane localization of p110alpha predisposes mammary glands to neoplastic transformation, young female mutant mice show delayed mammary gland involution and morphologic changes of the mammary ducts, which is more pronounced in old animals, especially in mutiparous females, in which increased ductal branching, alveolar hyperplasia, and intraductal neoplasia are observed, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
LY294002 a PI3K-specific inhibitor Homo sapiens
LY294002 a PI3K-specific inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate Mus musculus
-
 ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol-4,5-bisphosphate Homo sapiens
-
 ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adenosquamous carcinoma cell
-
 Mus musculus
-
breast cancer cell
-
 Homo sapiens
-
carcinoma cell
-
 Mus musculus
-
mammary gland
-
 Mus musculus
-
mammary gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate
-
 Mus musculus ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol-4,5-bisphosphate
-
 Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PI3K
-
 Mus musculus
PI3K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction PI3Ks constitute important regulators of various signaling pathways with relevance in cancer. Activation of PI3K by membrane localization of subunit p110alpha predisposes mammary glands to neoplastic transformation Mus musculus
malfunction PI3Ks constitute important regulators of various signaling pathways with relevance in cancer. Enhanced activation of p110A, the catalytic subunit of PI3K, woccurs in a high proportion of many human tumor types. Activation of PI3K by membrane localization of subunit p110alpha predisposes mammary glands to neoplastic transformation. Perturbation of the interaction of the CDK4/Rb/E2F cascade and the PI3K signaling occurs in many human cancers Homo sapiens