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Literature summary for 2.7.1.153 extracted from

  • Mammadova, G.; Iwasaki, T.; Tokmakov, A.A.; Fukami, Y.; Sato, K.I.
    Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization (2009), BMC Dev. Biol., 9, 68.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Inhibitors

Inhibitors Comment Organism Structure
LY294002 inhibits sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization. LY294002 also has an inhibitory effect on the Ca2+-dependent breakdown of the Mos protein kinase and cyclin B2 as well as dephosphorylation of mitogenactivated protein kinase Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Xenopus laevis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Xenopus laevis
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Xenopus laevis PIP3 acts as a positive regulator of the Src signaling pathway in Xenopus fertilization ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
 Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate PIP3 acts as a positive regulator of the Src signaling pathway in Xenopus fertilization Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PI 3-kinase
-
 Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Xenopus laevis

General Information

General Information Comment Organism
physiological function phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization. Inhibition of sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization, overview. PIP3 acts as a positive regulator of the Src signaling pathway in Xenopus fertilization Xenopus laevis