Literature summary for 2.7.1.153 extracted from

Okkenhaug, K.; Patton, D.T.; Bilancio, A.; Garcon, F.; Rowan, W.C.; Vanhaesebroeck, B.
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells (2006), J. Immunol., 177, 5122-5128.

Search for more literature for 2.7.1.153

Application

Application	Comment	Organism
medicine	p110delta may be a good target for pharmaceutical intervention of T cell-dependent autoimmune pathologies	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	Mus musculus	p110delta controls a critical checkpoint in peripheral T cell differentiation and clonal expansion	ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O35904	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	p110delta controls a critical checkpoint in peripheral T cell differentiation and clonal expansion	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
p110delta	-	Mus musculus

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Release 2023.1 (January 2023)