Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | increases catalytic activity. KM-for ribose and ATP decreases in a concentration-dependent manner | Homo sapiens | |
phosphate | marked dependency upon the presence of inorganic phosphate | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-carboxyethylphosphonic acid | - |
Escherichia coli | |
2-carboxyethylphosphonic acid | - |
Homo sapiens | |
ATP | substrate inhibition | Escherichia coli | |
ATP | substrate inhibition | Homo sapiens | |
clodronate | - |
Escherichia coli | |
clodronate | - |
Homo sapiens | |
D-ribose | substrate inhibition | Escherichia coli | |
D-ribose | substrate inhibition | Homo sapiens | |
etidronate | - |
Escherichia coli | |
etidronate | - |
Homo sapiens | |
N-(phosphonomethyl)-glycine | - |
Escherichia coli | |
N-(phosphonomethyl)-glycine | - |
Homo sapiens | |
N-(phosphonomethyl)iminodiacetic acid | - |
Escherichia coli | |
N-(phosphonomethyl)iminodiacetic acid | - |
Homo sapiens | |
Phosphonoacetic acid | - |
Escherichia coli | |
Phosphonoacetic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
ATP | 37°C, pH 7.0, in presence of 5 mM phosphate | Homo sapiens | |
0.08 | - |
ATP | 37°C, pH 7.0, in presence of 2 mM phosphate | Homo sapiens | |
0.1 | - |
ATP | 37°C, pH 7.0, in presence of 1 mM phosphate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-arabinose | weak activity | Homo sapiens | ? | - |
? | |
ATP + D-ribose | - |
Escherichia coli | ADP + D-ribose 5-phosphate | - |
? | |
ATP + D-ribose | - |
Homo sapiens | ADP + D-ribose 5-phosphate | - |
? | |
ATP + D-ribose | highly specific for ribose phosphorylation | Homo sapiens | ADP + D-ribose 5-phosphate | - |
? | |
additional information | no significant phosphorylation of D-fructose, D-galactose and D-xylose | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens | |
1.2 | - |
ATP | 37°C, pH 7.0, in presence of 1 mM phosphate | Homo sapiens | |
4.4 | - |
ATP | 37°C, pH 7.0, in presence of 2 mM phosphate | Homo sapiens | |
18.91 | - |
ATP | 37°C, pH 7.0, in presence of 5 mM phosphate | Homo sapiens |