Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NIH-12848 | full designation NCGC00012848-02, specific inhibitor of isoform PI5P4Kgamma, does not inhibit the alpha and beta PI5P4K isoforms at concentrations up to 0.1 mM; inhibitor of isoform PI5P4Kgamma only | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Mus musculus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione Sepharose column chromatography | Mus musculus |
glutathione Sepharose column chromatography, and gel filtration | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cortical collecting duct cell | - |
Mus musculus | - |
kidney cortical collecting duct cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 5-phosphate 4-kinase | - |
Mus musculus |
phosphatidylinositol 5-phosphate 4-kinase gamma | - |
Mus musculus |
PI5P4Kgamma | - |
Mus musculus |
PI5P4Kgamma | isoform | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.001 | - |
at pH 7.5 and 30°C | Mus musculus | NIH-12848 | |
0.001 | - |
at 22°C, pH not specified in the publication | Mus musculus | NIH-12848 |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of isoform PI5P4Kgamma increases when the cells grow to confluence and polarize | up |