Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)guanidine | i.e. idelalisib | Arabidopsis thaliana | |
LY294002 | competes with ATP and binds to Lys residues in the ATP-binding pocket of PI3Ks | Arabidopsis thaliana | |
Wortmannin | - |
Arabidopsis thaliana |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Arabidopsis thaliana | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
additional information | Arabidopsis thaliana | PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | P42339 | gene AtVPS34 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Arabidopsis thaliana | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
additional information | PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3-kinase | - |
Arabidopsis thaliana |
PI3K type III | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
evolution | PI3K type III is the only type of PI3K identified in plants | Arabidopsis thaliana |
malfunction | treatment with PI3K inhibitors or downregulation of AtVPS34 gene expression further suppressed V-ATPase activation in methyl jasmonate-induced leaf senescence. Downregulation of PI3K activity accelerates methyl jasmonate-induced leaf senescence. Vacuolar pH and the stomatal aperture also increased in the pi3k mutant and in treatments with PI3K inhibitors | Arabidopsis thaliana |
physiological function | phosphatidylinositol 3-kinase, PI3K, binds to VHA-B2 and promotes the activation of V-ATPase, resulting in vacuolar acidification and stomatal closure, thereby delaying methyl jasmonate-induced leaf senescence. PI3K is involved in the regulation of dark-induced senescence but does not function through the regulation of V-ATPase activity. PI3K regulates the activity of V-ATPase in MeJA-induced leaf senescence but not in dark-induced leaf senescence | Arabidopsis thaliana |