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Literature summary for 2.7.1.137 extracted from

  • Burrows, N.; Williams, J.; Telfer, B.A.; Resch, J.; Valentine, H.R.; Fitzmaurice, R.J.; Eustace, A.; Irlam, J.; Rowling, E.J.; Hoang-Vu, C.; West, C.M.; Brabant, G.; Williams, K.J.
    Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas (2016), Oncotarget, 7, 63106-63123.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
GDC-0941 enzyme PI3K-inhibition via GDC-0941 and PTEN-reconstitution into PTEN-null follicular thyroid carcinomas FTC-133s. GDC-0941 inhibits radiation-induced activation of Ataxia-telangiectasia mutated (ATM), ATM-and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Under anoxia, radiation-induced PI3K-related kinase activation is markedly inhibited by GDC-0941. Inhibition of ATM and DNA-protein kinase catalytic subunits is PI3K-dependent Homo sapiens
additional information the PI3K-related kinase proteins share significant sequence homology with PI3K, therefore drugs targeting PI3K may also inhibit PI3K-related kinase, PIKK, activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
thyroid carcinoma cell anaplastic and follicular thyroid carcinoma Homo sapiens
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Synonyms

Synonyms Comment Organism
phosphatidylinositide 3-kinase
-
 Homo sapiens
PI3K
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 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme PI3K can modify the PI3K-related kinases (PIKKs) in response to radiation. PIKKs interact with PI3K and contribute to radioresistance in thyroid-carcinomas Homo sapiens