Literature summary for 2.7.1.137 extracted from

Sahu, A.; Koshinaka, K.; Sahu, M.
Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus (2013), J. Neuroendocrinol., 25, 168-179.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Wortmannin	intracerebroventricular injection of leptin significantly increases phosphodiesterase 3B activity by twofold in the hypothalamus. Previous administration of wortmannin, a specific PI3K inhibitor, completely reverses the stimulatory effect of leptin on phosphodiesterase 3B activity in the hypothalamus	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hypothalamus	-	Rattus norvegicus	-

General Information

General Information	Comment	Organism
physiological function	intracerebroventricular injection of leptin significantly increases phosphodiesterase 3B activity by twofold in the hypothalamus. Previous administration of wortmannin, a specific PI3K inhibitor, completely reverses the stimulatory effect of leptin on phosphodiesterase 3B activity in the hypothalamus. PI3K but not Akt acts as an upstream regulator of the PDE3B pathway of leptin signalling in the rat hypothalamus	Rattus norvegicus

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Release 2023.1 (January 2023)