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Literature summary for 2.7.1.137 extracted from

  • Chae, C.H.; Kim, H.T.
    Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats (2009), Neurochem. Int., 55, 208-213.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
nerve growth factor activates the PI3-K/Akt signaling pathway Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Sprague–Dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PI3-K is activated by phosphorylation through serine/threonine protein kinases Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PI3-K
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism the PI3-K/Akt pathway plays a pivotal role in controlling the survival of neurons, although this activity declines during the aging process. NGF receptors and the PI3-K signaling pathway strongly influence cell survival Rattus norvegicus
physiological function the PI3-K/Akt pathway plays a pivotal role in controlling the survival of neurons, although this activity declines during the aging process. NGF receptors and the PI3-K signaling pathway strongly influence cell survival Rattus norvegicus