Literature summary for 2.7.1.137 extracted from

Sun, X.; Zhou, H.; Luo, X.; Li, S.; Yu, D.; Hua, J.; Mu, D.; Mao, M.
Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase (2008), Int. J. Dev. Neurosci., 26, 363-370.

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Inhibitors

Inhibitors	Comment	Organism	Structure
LY294002	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	embryonic	Rattus norvegicus	-
neuron	primary, cortical	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PI-3-K	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	PI-3-K and the PI-3-K signaling pathway, besides the MAPK signaling pathway, are involved in the signaling mechanism underlying the neuroprotection of brain-derived neurotrophic factor against hypoxic insult, molecular mechanisms, overview. ERK but not PI-3-K pathway induce CREB phosphorylation	Rattus norvegicus

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Release 2023.1 (January 2023)