Any feedback?
Literature summary for 2.7.1.137 extracted from
- BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway (2010), Exp. Cell Res., 316, 24-37.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bone morphogenetic protein-2 | activates Akt phopshorylation by PI3K. Cell treatment with BMP-2 exhibits dramatic changes in cell morphology, from a cuboid, epithelial-like shape to a spindle, fibroblastic-like appearance, consistent with epithelial-mesenchymal transition, EMT, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LY294002 | - |
Homo sapiens |  |
| noggin | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| AGS cell | - |
Homo sapiens | - |
| gastric cancer cell | - |
Homo sapiens | - |
| MKN-28 cell | - |
Homo sapiens | - |
| MKN-45 cell | - |
Homo sapiens | - |
| MKN-74 cell | - |
Homo sapiens | - |
| SNU-16 cell | - |
Homo sapiens | - |
| SNU-216 cell | - |
Homo sapiens | - |
| SNU-5 cell | - |
Homo sapiens | - |
| SNU-638 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 3-kinase | - |
Homo sapiens |
| PI3K | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | PI3K is part of the PI3K/Akt pathway, e.g. responsible for promoting motility and invasion of gastric cancer cells in epithelial-mesenchymal transition and metastasis, after activation and signaling by bone morphogenetic protein 2, BMP-2, with Snail induction, E-cadherin delocalization and down-regulation, and up-regulation of mesenchymal and invasiveness markers, overview | Homo sapiens |
| metabolism | PI3K is part of the PI3K/Akt pathway, e.g. responsible for promoting motility and invasion of gastric cancer cells in epithelial-mesenchymal transition and metastasis, after activation and signaling by bone morphogenetic protein 2, BMP-2, with Snail induction, E-cadherin delocalization and down-regulation, and up-regulation of mesenchymal and invasiveness markers, overview | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
