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Literature summary for 2.7.1.137 extracted from

  • Xie, P.; Williams, D.S.; Atilla-Gokcumen, G.E.; Milk, L.; Xiao, M.; Smalley, K.S.; Herlyn, M.; Meggers, E.; Marmorstein, R.
    Structure-based design of an Organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity (2008), ACS Chem. Biol., 3, 305-316.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine PI3K lipid kinase is an attractive target for the development of therapeutic agents to treat cancer and other related diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor E5E2, hanging drop vapour diffusion method, 100 mM Tris pH 7.2, 200 mM ammonium sulfate, 21% PEG 4000 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ead125
-
 Homo sapiens
Ly-294002
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidyl-inositol-3-kinase
-
 Homo sapiens
PI3Kgamma p110gamma catalytic subunit Homo sapiens