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Literature summary for 2.7.1.137 extracted from

  • Yang, P.H.; Cheung, W.K.; Peng, Y.; He, M.L.; Wu, G.Q.; Xie, D.; Jiang, B.H.; Huang, Q.H.; Chen, Z.; Lin, M.C.; Kung, H.F.
    Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal (2008), J. Biol. Chem., 283, 8486-8495.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus sp. overexpression of mkrn2 completely abrogates constitutively active PI3K- and Akt-induced, but not dominant negative glycogen synthase kinase-3beta-induced, neural cell adhesion molecule expression, indicating that mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta. Important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development ?
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Organism

Organism UniProt Comment Textmining
Xenopus sp.
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information overexpression of mkrn2 completely abrogates constitutively active PI3K- and Akt-induced, but not dominant negative glycogen synthase kinase-3beta-induced, neural cell adhesion molecule expression, indicating that mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta. Important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development Xenopus sp. ?
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