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Literature summary for 2.7.1.137 extracted from
- The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line (1994), J. Exp. Med., 179, 1799-1808.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Fyn may be directly involved in the activation of the downstream signaling enzyme, PI3-kinase, in IL-2-stimulated T cells | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | IL-2 stimulation triggers tyrosine phosphorylation of the p85 subunit of PI3-kinase in murine T cell line CTLL-2 | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | T cell line CTLL-2 | Mus musculus | - |
| T-lymphocyte | T cell line CTLL-2 | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidylinositol | - |
Mus musculus | ADP + phosphatidylinositol 3-phosphate | - |
? | |
| additional information | - |
Mus musculus | ? | - |
? | |
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