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Literature summary for 2.7.1.137 extracted from

  • Bavelloni, A.; Santi, S.; Sirri, A.; Riccio, M.; Faenza, I.; Zini, N.; Cecchi, S.; Ferri, A.; Auron, P.; Maraldi, N.M.; Marmiroli, S.
    Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells (1999), J. Cell Sci., 112, 631-640.
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Activating Compound

Activating Compound Comment Organism Structure
additional information direct association with the activated IL-1 receptor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in quiescent cells, PI3-kinase is distributed through the cytoplasm, although a portion is present in the nucleus, following stimulation with IL-1, PI3-kinase is redistributed, increasing in the nuclear compartment. PI3-kinase translocation to the nucleus upon IL-1R activation is an early event in IL-1 signaling mechanism, and may be involved in transcriptional activation Homo sapiens 5737
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nucleus in quiescent cells, PI3-kinase is distributed through the cytoplasm, although a portion is present in the nucleus, following stimulation with IL-1, PI3-kinase is redistributed, increasing in the nuclear compartment. PI3-kinase translocation to the nucleus upon IL-1R activation is an early event in IL-1 signaling mechanism, and may be involved in transcriptional activation Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture osteosarcoma Saos-2 cells Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
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 Homo sapiens ADP + phosphatidylinositol 3-phosphate
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