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Literature summary for 2.7.1.11 extracted from

  • Phong, W.; Lin, W.; Rao, S.; Dick, T.; Alonso, S.; Pethe, K.
    Characterization of phosphofructokinase activity in Mycobacterium tuberculosis reveals that a functional glycolytic carbon flow is necessary to limit the accumulation of toxic metabolic intermediates under hypoxia (2013), PLoS ONE, 8, e56037.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex 200 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
Mycobacterium tuberculosis ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Mycobacterium tuberculosis H37Rv ADP + D-fructose 1,6-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
PFKA isozyme Mycobacterium tuberculosis
phosphofructokinase
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function isozyme PFKA is required for growth on glucose as sole carbon source. The isoform is also required for survival of hypoxic non-replicating Mycobaterium tuberculosis but is not required for virulence and survival in the mouse model of tuberculosis infection Mycobacterium tuberculosis