Literature summary for 2.7.1.11 extracted from

Marinho-Carvalho, M.M.; Costa-Mattos, P.V.; Spitz, G.A.; Zancan, P.; Sola-Penna, M.
Calmodulin upregulates skeletal muscle 6-phosphofructo-1-kinase reversing the inhibitory effects of allosteric modulators (2009), Biochim. Biophys. Acta, 1794, 1175-1180.

Search for more literature for 2.7.1.11

Activating Compound

Activating Compound	Comment	Organism	Structure
ADP	-	Oryctolagus cuniculus
Calmodulin	binding of one calmodulin per monomer promotes the dimerization of the enzyme although maintaining its full catalytic activity, 30 nM calmodulin activates 6-phosphofructo-1-kinase in the presence of its inhibitors citrate and lactate	Oryctolagus cuniculus
D-fructose 2,6-bisphosphate	-	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
ATP	the inhibition of enzyme activity by ATP (above 1 mM) is abolished in the presence of calmodulin	Oryctolagus cuniculus
citrate	-	Oryctolagus cuniculus
Lactate	-	Oryctolagus cuniculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	calmodulin binding to the enzyme is stimulated by 0.01 mM Ca2+	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-fructose 6-phosphate	-	Oryctolagus cuniculus	ADP + D-fructose 1,6-bisphosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	calmodulin-bound dimers are active and less susceptible to inhibition by allosteric ligands, 5 mM ATP stabilizes phosphofructokinase dimers	Oryctolagus cuniculus

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-1-kinase	-	Oryctolagus cuniculus
ATP:D-fructose-6-phosphate-1-phosphotransferase	-	Oryctolagus cuniculus
PFK	-	Oryctolagus cuniculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)