Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.11 extracted from

  • Kamp, G.; Schmidt, H.; Stypa, H.; Feiden, S.; Mahling, C.; Wegener, G.
    Regulatory properties of 6-phosphofructokinase and control of glycolysis in boar spermatozoa (2007), Reproduction, 133, 29-40.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
AMP activates Sus scrofa
AMP at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects Sus scrofa
D-fructose 2,6-bisphosphate activates Sus scrofa
fructose 2,6-bisphosphate at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
ATP at physiological concentration; at physiological pH, the enzyme is allosterically inhibited by near-physiological concentrations of its co-substrate ATP, which induces cooperativity, i.e. reduces the affinity for the substrate fructose 6-phosphate. Inhibition by ATP is reinforced by citrate and H+ Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
acrosome
-
Sus scrofa
-
-
flagellum
-
Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa 6-phosphofructokinase is the most important element for control of glycolytic flux ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-
Sus scrofa
-
boar
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
spermatozoon localized in the mid-piece and principal piece of the flagellum as well as in the acrosomal area at the top of the head and in the cytoplasmic droplets released from the mid-piece after ejaculation Sus scrofa
-
spermatozoon PFK shows no tight binding to sperm structures. It can readily be extracted from ejaculated boar spermatozoa by sonication. PFK is localized in the mid-piece and principal piece of the flagellum as well as in the acrosomal area at the top of the head and in the cytoplasmic droplets released from the mid-piece after ejaculation Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 6-phosphofructokinase is the most important element for control of glycolytic flux Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
PFK
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
above pH 8, the enzyme loses all its regulatory properties and shows maximal activity Sus scrofa
8
-
above pH 8, PFK lost all its regulatory properties and showed maximum activity Sus scrofa