Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | activates | Sus scrofa | |
AMP | at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects | Sus scrofa | |
D-fructose 2,6-bisphosphate | activates | Sus scrofa | |
fructose 2,6-bisphosphate | at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | at physiological concentration; at physiological pH, the enzyme is allosterically inhibited by near-physiological concentrations of its co-substrate ATP, which induces cooperativity, i.e. reduces the affinity for the substrate fructose 6-phosphate. Inhibition by ATP is reinforced by citrate and H+ | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
acrosome | - |
Sus scrofa | - |
- |
flagellum | - |
Sus scrofa | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sus scrofa | 6-phosphofructokinase is the most important element for control of glycolytic flux | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Sus scrofa | - |
boar | - |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spermatozoon | localized in the mid-piece and principal piece of the flagellum as well as in the acrosomal area at the top of the head and in the cytoplasmic droplets released from the mid-piece after ejaculation | Sus scrofa | - |
spermatozoon | PFK shows no tight binding to sperm structures. It can readily be extracted from ejaculated boar spermatozoa by sonication. PFK is localized in the mid-piece and principal piece of the flagellum as well as in the acrosomal area at the top of the head and in the cytoplasmic droplets released from the mid-piece after ejaculation | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | 6-phosphofructokinase is the most important element for control of glycolytic flux | Sus scrofa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PFK | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
above pH 8, the enzyme loses all its regulatory properties and shows maximal activity | Sus scrofa |
8 | - |
above pH 8, PFK lost all its regulatory properties and showed maximum activity | Sus scrofa |