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Literature summary for 2.7.1.11 extracted from

  • Kamemoto, E.S.; Iltzsch, M.H.; Lan, L.; Mansour, T.E.
    Phosphofructokinase from Fasciola hepatica: activation by phosphorylation and other regulatory properties distinct from the mammalian enzyme (1987), Arch. Biochem. Biophys., 258, 101-111.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
AMP activation Fasciola hepatica
AMP one of three most potent activators Fasciola hepatica
cAMP-dependent protein kinase activation by phosphorylation Fasciola hepatica
cAMP-dependent protein kinase kinetics, one of three most potent activators Fasciola hepatica
D-fructose 1,6-bisphosphate activation Fasciola hepatica
D-fructose 2,6-bisphosphate activation of native and phosphorylated PFK, one of three most potent activators Fasciola hepatica
D-Glucose 1,6-bisphosphate activation Fasciola hepatica

Inhibitors

Inhibitors Comment Organism Structure
Aldolase
-
Fasciola hepatica
Aldolase
-
Ovis aries
ATP
-
Fasciola hepatica
ATP
-
Ovis aries
citrate strong inhibition; weak inhibition Fasciola hepatica
citrate strong inhibition; weak inhibition Ovis aries
phosphatase dephosphorylation inactivates Fasciola hepatica
phosphatase dephosphorylation inactivates Ovis aries

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic study Ovis aries
additional information
-
additional information kinetic study Fasciola hepatica
additional information
-
additional information allosteric kinetics at alkaline pH-values Fasciola hepatica
additional information
-
additional information kinetic properties of phosphorylated enzyme Ovis aries
additional information
-
additional information kinetic properties of phosphorylated enzyme Fasciola hepatica

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
Fasciola hepatica
Mg2+ required for activity Ovis aries
Mg2+ required for activity Fasciola hepatica

Organism

Organism UniProt Comment Textmining
Fasciola hepatica
-
-
-
Ovis aries
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification
-
Fasciola hepatica

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
Ovis aries ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Fasciola hepatica ADP + D-fructose 1,6-bisphosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
native enzyme Fasciola hepatica
7.6
-
phosphorylated enzyme Fasciola hepatica