Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(S)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propan-1-ol | analogue of FTY720, 0.01 mM increase phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoform diacylglycerol kinase alpha about 3.5fold. | Homo sapiens | |
FTY720 | in presence of 0.01 mM FTY720, phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoforms diacylglycerol kinase alpha, beta or gamma is 3fold increased | Homo sapiens | |
sphingosine | in presence of 0.01 mM sphingosine, phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoforms diacylglycerol kinase alpha, beta or gamma is 7-9fold increased | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-dioleoyl-sn-glycerol | about 15fold the rate of 1-O-hexadecyl-sn-glycerol phosphorylation, isoforms diacylglycerol kinase alpha, beta, gamma, delta1, delta1, zeta, jota, theta | Homo sapiens | ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1-O-hexadecyl-2-sn-acetyl glycerol | about 12fold the rate of 1-O-hexadecyl-sn-glycerol phosphorylation, isoforms diacylglycerol kinase alpha, beta, gamma, delta1, delta1, zeta, jota, theta | Homo sapiens | ADP + 1-O-hexadecyl-2-sn-acetyl glycerol 3-phosphate | - |
? | |
ATP + 1-O-hexadecyl-sn-glycerol | - |
Homo sapiens | ADP + 1-O-hexadecyl-sn-glycerol 3-phosphate | - |
? | |
additional information | alkyl-lysophosphatidic acid can be produced in SKOV-3 cells by diacylglycerol kinase-mediated phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol followed by deacetylation of 1-O-hexadecyl-sn-2-acetyl glycerol 3-phosphate. Production of alkyl-lysophosphatidic acid is stimulated by sphingosine and its analogues | Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | treating SKOV-3 ovarian cancer cell with a sphingosine analogue stimulates conversion of exogenous 1-alkyl-2-acetyl glycerol to alkyl-lysophosphatidic acid. Diacylglycerol kinase alpha may contribute significantly to the production of alkyl-lysophosphatidic acid in SKOV-3 cells, showing cross-talk between the sphingolipid and glycerol lipid pathways | Homo sapiens |