Application | Comment | Organism |
---|---|---|
synthesis | overexpression of HXK1 in a highly modified strain of Yarrowia lipolytica W29 engineered to optimize oil production, combined with Saccharomyces cerevisiae invertase gene expression. For the recombinant strain, sucrose is a better substrate than either of its building blocks, glucose or fructose. Over its 96 h of growth in the bioreactors, this strain produces 9.15g/l of lipids, yielding 0.262g/g of biomass | Yarrowia lipolytica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yarrowia lipolytica | O74996 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Hxk1 | - |
Yarrowia lipolytica |
General Information | Comment | Organism |
---|---|---|
physiological function | Overexpression of the HXK1 gene leads to increased hexokinase activity (6.5-12 times higher), a pronounced reduction in cell filamentation in overexpressing strains grown in fructose-based media, and improved biomass production. All overexpressing strains show improved lipid yield and production when grown on fructose, although th eeffect is strain-dependent (23-55% improvement) | Yarrowia lipolytica |