Literature summary for 2.7.1.1 extracted from

Sen, S.; Kaminiski, R.; Deshmane, S.; Langford, D.; Khalili, K.; Amini, S.; Datta, P.K.
Role of hexokinase-1 in the survival of HIV-1-infected macrophages (2015), Cell Cycle, 14, 980-989.

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Application

Application	Comment	Organism
medicine	HIV-1 induces a robust increase in hexokinase-1 expression. Hexokinase enzymatic activity is significantly inhibited in HIV-1 infected peripheral blood mononuclear cells and in phorbol 12-myristate 13-acetate differentiated U1 cells. Increased levels of mitochondria-bound hexokinase -1are observed in phorbol 12-myristate 13-acetate-induced U1 cells and in the HIV-1 accessory protein, viral protein R transduced U937 cell derived macrophages. Dissociation of hexokinase-1 from mitochondria in U1 cells using clotrimazole induces mitochondrial membrane depolarization and caspase-3/7 mediated apoptosis. Dissociation of hexokinase-1 from mitochondria in viral protein R transduced U937 also activates caspase-3/7 activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Homo sapiens	-
monocyte	-	Homo sapiens	-
peripheral blood mononuclear cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HK-1	-	Homo sapiens

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Release 2023.1 (January 2023)