Protein Variants | Comment | Organism |
---|---|---|
C5A | mutation abrogates palmitoylation of protein | Homo sapiens |
C5S | mutation abrogates palmitoylation of protein | Homo sapiens |
G2A | mutant protein lacks myristoylation | Homo sapiens |
G2A/C5S | mutation abrogates both myristoylation and palmitoylation of protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | compartmentalization of hexokinase-1 to plasma membrane of sperm cells is swappable to somatic HEK-293 cells | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19367 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
lipoprotein | The N-terminal MGQICQ motif in the unique germ cell-specific domain of hexokinase acquires hydrophobicity by N-myristoylation and palmitoylation. The mutation of the myristoyl recipient Gly2 impedes plasma membrane association and relocates the enzyme to the cytosol but not the nucleus. Substitution of the putatively palmitoylated Cys5 is reflected in a similar loss of compartmentalization of the protein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
sperm | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
hexokinase-1 | - |
Homo sapiens |