Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.1 extracted from

  • John, S.; Weiss, J.N.; Ribalet, B.
    Subcellular localization of hexokinases I and II directs the metabolic fate of glucose (2011), PLoS ONE, 6, e17674.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
HKI and HKII linked to YFP are expressed in CHO-cells to track their subcellular location in real time and their mobilization in response to substrates Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol HKII translocates between mitochondria and the cytosol in response to glucose, glucose 6-phosphate and Akt Rattus norvegicus 5829
-
mitochondrion HKI remains strongly bound to mitochondria Rattus norvegicus 5739
-
mitochondrion HKII translocates between mitochondria and the cytosol in response to glucose, glucose 6-phosphate and Akt Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
HKI
-
Rattus norvegicus
HKII
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism HKI exclusively promotes glycolysis Rattus norvegicus
metabolism HKII promotes glycolysis when bound to mitochondria. Promotes glycogen synthesis when located in the cytosol Rattus norvegicus