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Literature summary for 2.7.1.1 extracted from
- Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver (2009), Vet. Res. Commun., 33, 227-240.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucokinase regulatory protein | binds glucokinase in the nucleus and inhibits its activity | Canis lupus familiaris | |
| glucokinase regulatory protein | binds glucokinase in the nucleus and inhibits its activity | Felis catus | |
| glucokinase regulatory protein | binds glucokinase in the nucleus and inhibits its activity | Rattus norvegicus | |
| additional information | not inhibited by D-glucose-6-phosphate | Canis lupus familiaris | |
| additional information | not inhibited by D-glucose-6-phosphate | Felis catus | |
| additional information | not inhibited by D-glucose-6-phosphate | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | glucokinase becomes active when it is released from glucokinase regulatory protein and translocates to the cytosol | Rattus norvegicus | 5829 | - |
| cytosol | glucokinase becomes active when it is released from glucokinase regulatory protein and translocates to the cytosol | Canis lupus familiaris | 5829 | - |
| cytosol | glucokinase becomes active when it is released from glucokinase regulatory protein and translocates to the cytosol | Felis catus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Felis catus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Canis lupus familiaris | - |
| liver | - |
Felis catus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-glucose | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? |  |
| ATP + D-glucose | - |
Canis lupus familiaris | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Felis catus | ADP + D-glucose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glucokinase | - |
Rattus norvegicus |
| glucokinase | - |
Canis lupus familiaris |
| glucokinase | - |
Felis catus |
| HK4 | - |
Rattus norvegicus |
| HK4 | - |
Canis lupus familiaris |
| HK4 | - |
Felis catus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Canis lupus familiaris | |
| ATP | - |
Felis catus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | glucokinase acts as a hepatic glucose sensor that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations | Rattus norvegicus |
| physiological function | glucokinase acts as a hepatic glucose sensor that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations | Canis lupus familiaris |
| physiological function | glucokinase acts as a hepatic glucose sensor that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations | Felis catus |
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Release 2023.1 (January 2023)
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