Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-cyclopentyl-2-[4-(cyclopropylsulfonyl)phenyl]-N-[4-(1,2-dihydroxyethyl)-1,3-thiazol-2-yl]prop-2-enamide | - |
Homo sapiens | |
2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide | - |
Homo sapiens | |
2-[(3-cyclopentyl-2-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]propanoyl)amino]-5-methoxy-1H-[1,3]thiazolo[5,4-b]pyridin-3-ium | - |
Homo sapiens | |
3-(5-chloro-1,3-thiazol-2-yl)-1-[4-(methylsulfonyl)phenyl]-1-(thiophen-2-ylmethyl)urea | - |
Homo sapiens | |
4-[4-(dimethylcarbamoyl)-3-fluorophenoxy]-2-ethyl-2-methyl-N-(5-methylpyridin-2-yl)-2,3-dihydro-1-benzofuran-6-carboxamide | - |
Homo sapiens | |
5-(2-methylpropyl)-N-(1,3-thiazol-2-yl)-1H-indazol-3-amine | - |
Homo sapiens | |
fructose | - |
Homo sapiens | |
GKA50 | - |
Homo sapiens | |
N,N-dicyclohexyl-N'-methyldicarbonimidic diamide | - |
Homo sapiens | |
N-(4-methyl-1,3-thiazol-2-yl)-3-(pyridin-3-ylmethoxy)pyridin-2-amine | - |
Homo sapiens | |
RO-281675 | - |
Homo sapiens | |
RO-4389620 | also known as R1440, GK2, or piragliatin | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | activation of glucokinase as glucose lowering therapy for type 2 diabetes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T65I | mutant shows reduced activity (41%) compared to the wild type enzyme | Homo sapiens |
V455M | mutant shows increased activity (108%) compared to the wild type enzyme | Homo sapiens |
W99R | mutant shows slightly increased activity (219%) compared to the wild type enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
pancreatic beta cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
glucokinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | heterozygous or homozygous loss of function in the glucokinase gene causes either mild diabetes (maturity onset diabetes of the young type 2 [MODY2]) or severe neo-natal onset diabetes, respectively | Homo sapiens |