Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bad peptide | - |
Rattus norvegicus | |
glucokinase-associated phosphatase | - |
Rattus norvegicus | |
additional information | not affected by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | Rattus norvegicus | |
pentaubiquitin | - |
Rattus norvegicus | |
propionyl-CoA carboxylase beta-subunit | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glucokinase regulatory protein | binding of fructose 6-phosphate to glucokinase regulatory protein favors the glucokinase regulatory protein-glucokinas interaction with a negative effect on enzyme activity, while binding of fructose-1-phosphate weakens the glucokinase regulatory protein-glucokinase interaction and releases active glucokinase, the reversible association of glucokinase with glucokinase regulatory protein does more than simply regulate the catalytic activity of glucokinase, it also appears to underlie the intracellular trafficking of glucokinase between cytoplasm and nucleus | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | glucose levels higher 5 mM or fructose addition to the medium causes a rapid translocation of glucokinase to a predominant cytoplasmic localization | Rattus norvegicus | 5737 | - |
nucleus | glucokinase is mainly localized to the nuclei at glucose concentrations around 5 mM | Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
hexose + ATP | - |
Rattus norvegicus | ADP + hexose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCK | - |
Rattus norvegicus |
glucokinase | - |
Rattus norvegicus |
hexokinase D | - |
Rattus norvegicus |
hexokinase IV | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | in the liver, expression of glucokinase is strictly dependent on the presence of insulin, insulin induction of glucokinase in hepatocytes is suppressed by the inhibitors of phosphoinositide 3-kinase, wortmannin, and LY294002 | up |