Literature summary for 2.7.1.1 extracted from

Nishimasu, H.; Fushinobu, S.; Shoun, H.; Wakagi, T.
Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii (2007), J. Biol. Chem., 282, 9923-9931.

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method at 25°C. Crystal structures of StHK in four different forms: (i) apo-form, (ii) binary complex with glucose, (iii) binary complex with ADP, and (iv) quaternary complex with xylose, Mg2+, and ADP. Forms i and iii are in the open state, and forms ii and iv are in the closed state, indicating that sugar binding induces a large conformational change, whereas ADP binding does not	Sulfurisphaera tokodaii
hanging drop vapor diffusion method. Crystal structures of StHK in four different forms: (i) apo-form, (ii) binary complex with glucose, (iii) binary complex with ADP, and (iv) quaternary complex with xylose, Mg2+, and ADP. Forms i and iii are in the open state, and forms ii and iv are in the closed state, indicating that sugar binding induces a large conformational change, whereas ADP binding does not	Sulfurisphaera tokodaii

Crystallization (Comment)

Organism

hanging drop vapor diffusion method at 25°C. Crystal structures of StHK in four different forms: (i) apo-form, (ii) binary complex with glucose, (iii) binary complex with ADP, and (iv) quaternary complex with xylose, Mg2+, and ADP. Forms i and iii are in the open state, and forms ii and iv are in the closed state, indicating that sugar binding induces a large conformational change, whereas ADP binding does not

Sulfurisphaera tokodaii

hanging drop vapor diffusion method. Crystal structures of StHK in four different forms: (i) apo-form, (ii) binary complex with glucose, (iii) binary complex with ADP, and (iv) quaternary complex with xylose, Mg2+, and ADP. Forms i and iii are in the open state, and forms ii and iv are in the closed state, indicating that sugar binding induces a large conformational change, whereas ADP binding does not

Sulfurisphaera tokodaii

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	direct visualization of the binding mode for magnesium to hexokinase	Sulfurisphaera tokodaii

Organism

Organism	UniProt	Comment	Textmining
Sulfurisphaera tokodaii	Q96Y14	-	-
Sulfurisphaera tokodaii 7	Q96Y14	-	-

Synonyms

Synonyms	Comment	Organism
ATP-dependent hexokinase	-	Sulfurisphaera tokodaii
StHK	-	Sulfurisphaera tokodaii

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Release 2023.1 (January 2023)