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Literature summary for 2.7.1.1 extracted from
- Hexokinase in astrocytes: Kinetic and regulatory properties (1999), Metab. Brain Dis., 14, 125-133.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-glucose 1,6-diphosphate | at concentrations higher than 0.2 mM, inhibits in a concentration-dependent manner, 1.2 mM: almost complete inhibition | Mus musculus |  |
| glucose 1,6-disphosphate | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.208 | - |
ATP | MgATP2- | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolute requirement for MgATP2- and Mg2+ | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | Mus musculus | key enzyme in the control of brain glucose metabolism | D-glucose 6-phosphate + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
newborn mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | cerebrocortical astrocytes in primary culture, prepared from the neopallium | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
| 0.033 | 0.04 | - |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | absolute requirement for D-glucose | Mus musculus | ADP + D-glucose 6-phosphate | - |
? | |
| D-glucose + ATP | key enzyme in the control of brain glucose metabolism | Mus musculus | D-glucose 6-phosphate + ADP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 8 | - |
Mus musculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | 9.2 | at pH 5.6: 70% of maximum activity, at pH 9.2: 50% of maximum activity | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | absolute requirement for MgATP2- | Mus musculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
glucose 1,6-disphosphate | IC50 | Mus musculus | |
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