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Literature summary for 2.7.1.1 extracted from
- Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes (1982), Biochim. Biophys. Acta, 719, 431-437.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-glucose | at high concentrations; inhibits hexokinase III | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | in granulocytes and erythrocytes most of the hexokinase activity is found in the cytosol | Homo sapiens | 5829 | - |
| particle-bound | in lymphocytes and platelets most of the hexokinase activity is particle-bound | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | Homo sapiens | glycolytic enzyme | D-glucose 6-phosphate + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
hexokinase types I and III | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | contains only hexokinase I | Homo sapiens | - |
| erythrocyte | contains a multibanded type I hexokinase | Homo sapiens | - |
| granulocyte | 70-80% hexokinase III, 20-30% hexokinase I | Homo sapiens | - |
| lymphocyte | contains mainly hexokinase I and a minor amount of hexokinase III in the soluble fraction, less than 10% | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? | |
| D-glucose + ATP | glycolytic enzyme | Homo sapiens | D-glucose 6-phosphate + ADP | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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