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Literature summary for 2.7.1.1 extracted from

  • Nemat-Gorgani, M.; Wilson, J.E.
    Acidic phospholipids may inhibit rat brain hexokinase by interaction at the nucleotide binding site (1985), Arch. Biochem. Biophys., 236, 220-227.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acidic phospholipids irreversible inhibition, binds at the nucleotide-binding site of enzyme, ATP and glucose 6-phosphate protect, effectiveness of various ligands in protection against inhibition, effect of pH and temperature Rattus norvegicus
cardiolipin effectiveness of various ligands in protection against inhibition, effect of pH and temperature Rattus norvegicus
Cibacron blue competitive to ATP Rattus norvegicus
D-glucose 6-phosphate reversible product inhibition Rattus norvegicus
additional information not inhibited by 1 mM phosphatidylethanolamine or phosphatidylcholine Rattus norvegicus
phosphatidylinositol effectiveness of various ligands in protection against inhibition, effect of pH and temperature Rattus norvegicus
phosphatidylserine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo Rattus norvegicus 5741
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + ATP Rattus norvegicus binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate D-glucose 6-phosphate + ADP
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + ATP
-
Rattus norvegicus ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate Rattus norvegicus D-glucose 6-phosphate + ADP
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus