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Literature summary for 2.7.1.1 extracted from
- Characterization of Trypanosoma cruzi hexokinase (1983), Mol. Biochem. Parasitol., 9, 181-188.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-thio-D-glucose | marked inhibition | Trypanosoma cruzi |  |
| ADP | noncompetitive to glucose, competitive to ATP | Trypanosoma cruzi | |
| additional information | not inhibited by D-glucose 6-phosphate | Trypanosoma cruzi | |
| N-acetyl-D-glucosamine | competitive to glucose | Trypanosoma cruzi | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.09 | - |
D-glucose | - |
Trypanosoma cruzi | |
| 0.4 | - |
ATP | - |
Trypanosoma cruzi | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
hexokinase I | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epimastigote | - |
Trypanosoma cruzi | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | - |
Trypanosoma cruzi | ADP + D-glucose 6-phosphate | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Trypanosoma cruzi | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
N-acetyl-D-glucosamine | - |
Trypanosoma cruzi | |
| 0.4 | - |
5-thio-D-glucose | - |
Trypanosoma cruzi | |
| 1.5 | - |
ADP | competitive to ATP | Trypanosoma cruzi | |
| 7 | - |
ADP | noncompetitive to glucose | Trypanosoma cruzi | |
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