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Literature summary for 2.6.1.19 extracted from

  • Awad, R.; Muhammad, A.; Durst, T.; Trudeau, V.L.; Arnason, J.T.
    Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity (2009), Phytother. Res., 23, 1075-1081.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information the methanol extract from Melissa officinalis is a potent in vitro inhibitor of GABA-T with IC50 of 0.55 mg/ml, inhibition decreases in the order: methanol extract, water extract, ethyl acetate extract and hexane extract (not inhibitory) Rattus norvegicus
oleanolic acid 20.2% inhibition at 0.1 mg/ml Rattus norvegicus
rosmarinic acid 40.2% inhibition at 0.1 mg/ml Rattus norvegicus
ursolic acid 19.9% inhibition at 0.1 mg/ml Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate Rattus norvegicus
-
4-oxobutanoate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
Rattus norvegicus 4-oxobutanoate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GABA transaminase
-
Rattus norvegicus
GABA-T
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus