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Literature summary for 2.6.1.19 extracted from

  • Clift, M.D.; Silverman, R.B.
    Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase (2008), Bioorg. Med. Chem. Lett., 18, 3122-3125.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.19

Crystallization (Commentary)

Crystallization (Comment) Organism
docking calculations for substrates 3-(aminomethyl)benzoic acid, [3-(aminomethyl)phenyl]acetic acid and [2-(aminomethyl)phenyl]acetic acid, using the crystallographic structure of the enzyme in complex with vigabatrin Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
3-(aminomethyl)benzoic acid poor competitive inhibitor Sus scrofa
[2-(aminomethyl)phenyl]acetic acid poor competitive inhibitor Sus scrofa
[3-(aminomethyl)phenyl]acetic acid poor competitive inhibitor Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P80147
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(aminomethyl)benzoic acid + 2-oxoglutarate 3.4% of the activity with 4-aminobutanoate Sus scrofa 3-(iminomethyl)benzoic acid + L-glutamate
-
 ?
4-aminobutanoate + 2-oxoglutarate
-
 Sus scrofa 4-oxobutanoate + L-glutamate
-
 ?
[2-(aminomethyl)phenyl]acetic acid + 2-oxoglutarate 5.65% of the activity with 4-aminobutanoate Sus scrofa (2-formylphenyl)acetic acid + L-glutamate
-
 ?
[3-(aminomethyl)phenyl]acetic acid + 2-oxoglutarate 0.78% of the activity with 4-aminobutanoate Sus scrofa (3-formylphenyl)acetic acid + L-glutamate
-
 ?