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Literature summary for 2.6.1.19 extracted from

  • Wang, Z.; Silverman, R.B.
    Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase (2006), Bioorg. Med. Chem., 14, 2242-2252.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+/-)-(1S,2R,4S,5S)-4-amino-6,6-difluorobicyclo[3.1.0]hexane-2-carboxylic acid 10 mM, weak, reversible inhibitor Sus scrofa
(+/-)-(1S,2S,4S,5S)-4-amino-6,6-difluorobicyclo[3.1.0]hexane-2-carboxylic acid 10 mM, weak, reversible inhibitor Sus scrofa
3-aminocyclohexanecarboxylic acid 10 mM Sus scrofa
4-amino-5-fluoropentanoic acid potent irreversible inhibitor Sus scrofa
additional information (+/-)-(1S,3S,4S)-3-amino-4-fluorocyclohexanecarboxylic acid and (cis)-3-amino-5,5-difluorocylcohexanecarboxylic acid are no an inhibitors of GABA-AT at a concentration of 10 mM Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
Sus scrofa 4-oxobutanoate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GABA-AT
-
Sus scrofa
gamma-aminobutyric acid aminotransferase
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Sus scrofa