Literature summary for 2.5.1.78 extracted from

Ritsert, K.; Huber, R.; Turk, D.; Ladenstein, R.; Schmidt-B�se, K.; Bacher, A.
Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution (1995), J. Mol. Biol., 253, 151-167.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor (5-nitro-6-(D-ribitylamino)-2,4(1H,3H)-pyrimidinedione) at 2.4 A resolution	Bacillus subtilis

Inhibitors

Inhibitors	Comment	Organism	Structure
5-nitro-6-(D-ribitylamino)-2,4(1H,3H)-pyrimidinedione	-	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Bacillus subtilis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?

Subunits

Subunits	Comment	Organism
More	the bifunctional lumazine synthase/riboflavin synthase (EC 2.5.1.9) complex is composed of 3 alpha (riboflavin synthase) subunits and 60 beta (lumazine synthase) subunits and has a relative mass of 1 MDa. The 60 beta subunits are arranged in an icosahedral capsid enclosing the alpha trimer in the central core. Hollow, icosahedral capsids consisting of 60 beta subunits can be obtained by inhibitor-driven renaturation of isolated beta subunits. They catalyse the formation of 6,7-dimethyl-8-ribityllumazine at the same rate as the native alpha3beta60 complex and can be crystallised in two different hexagonal and one monoclinic form	Bacillus subtilis

Synonyms

Synonyms	Comment	Organism
lumazine synthase/riboflavin synthase complex	bifunctional enzyme complex	Bacillus subtilis

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Release 2023.1 (January 2023)