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Literature summary for 2.5.1.78 extracted from

  • Haase, I.; Fischer, M.; Bacher, A.; Schramek, N.
    Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus (2003), J. Biol. Chem., 278, 37909-37915.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one 4-phosphate Aquifex aeolicus
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 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H2O + phosphate
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Organism

Organism UniProt Comment Textmining
Aquifex aeolicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one 4-phosphate
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 Aquifex aeolicus 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H2O + phosphate
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 ?
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one 4-phosphate an early optical transient absorbing around 330 nm is interpreted as a Schiff base intermediate obtained by reaction of the position 5 amino group of the heterocyclic substrate with the carbonyl group of 3,4-dihydroxy-2-butanone 4-phosphate. A second transient with an absorption maximum at 445 nm represents an intermediate resulting from the elimination of phosphate from the Schiff base. The rate-determining step is the subsequent formation of the 7-exomethylene type anion of 6,7-dimethyl-8-ribityllumazine Aquifex aeolicus 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H2O + phosphate
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 ?

Synonyms

Synonyms Comment Organism
6,7-dimethyl-8-ribityllumazine synthase
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 Aquifex aeolicus