Literature summary for 2.5.1.78 extracted from

Morgunova, E.; Illarionov, B.; Sambaiah, T.; Haase, I.; Bacher, A.; Cushman, M.; Fischer, M.; Ladenstein, R.
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis (2006), FEBS J., 273, 4790-4804.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals are obtained in sitting drops by the vapour diffusion technique with the macroseeding procedure	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
1,3,7-trihydro-9-D-ribityl-2,4,8-purinetrione	association constants and thermodynamic parameters of binding	Mycobacterium tuberculosis
4-(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-yl)butyl 1-phosphate	association constants and thermodynamic parameters of binding	Mycobacterium tuberculosis
5-(1,3,7-trihydro-9-d-ribityl-2,4,8-purinetrione-7-yl)1,1-difluoropentane-1-phosphate	association constants and thermodynamic parameters of binding	Mycobacterium tuberculosis
5-(1,3,7-trihydro-9-D-ribityl-2,4,8-purinetrione-7-yl)pentane1-phosphate	association constants and thermodynamic parameters of binding	Mycobacterium tuberculosis
6-(1,3,7-trihydro-9-d-ribityl-2,4,8-purinetrione-7-yl)hexane 1-phosphate	association constants and thermodynamic parameters of binding	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

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Release 2023.1 (January 2023)