Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.78 extracted from

  • Yu, T.Y.; O'Connor, R.D.; Sivertsen, A.C.; Chiauzzi, C.; Poliks, B.; Fischer, M.; Bacher, A.; Haase, I.; Cushman, M.; Schaefer, J.
    15N(31)P REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase (2008), Biochemistry, 47, 13942-13951.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate Saccharomyces cerevisiae
-
6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate
-
Saccharomyces cerevisiae 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. The Lys92 side chain could facilitate the exchange of inorganic phosphate eliminated from the substrate in one reaction, with the organic phosphate-containing substrate necessary for the next reaction Saccharomyces cerevisiae 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?