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Literature summary for 2.5.1.7 extracted from
- UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments (2011), Appl. Microbiol. Biotechnol., 92, 211-225.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-tuliposide A | potent inhibitor | Enterobacter cloacae |  |
| 1-tuliposide A | potent inhibitor | Escherichia coli | |
| 1-tuliposide A | potent inhibitor | Mycobacterium tuberculosis | |
| 1-tuliposide A | potent inhibitor | Pseudomonas aeruginosa | |
| 1-tuliposide A | potent inhibitor | Staphylococcus aureus | |
| 1-tuliposide A | potent inhibitor | Streptococcus pneumoniae | |
| 1-tuliposide B | potent inhibitor | Enterobacter cloacae | |
| 1-tuliposide B | potent inhibitor | Escherichia coli | |
| 1-tuliposide B | potent inhibitor | Mycobacterium tuberculosis | |
| 1-tuliposide B | potent inhibitor | Pseudomonas aeruginosa | |
| 1-tuliposide B | potent inhibitor | Staphylococcus aureus | |
| 1-tuliposide B | potent inhibitor | Streptococcus pneumoniae | |
| 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Enterobacter cloacae | |
| 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Escherichia coli | |
| 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Mycobacterium tuberculosis | |
| 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Pseudomonas aeruginosa | |
| 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Staphylococcus aureus | |
| 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Streptococcus pneumoniae | |
| 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Enterobacter cloacae | |
| 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Escherichia coli | |
| 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Mycobacterium tuberculosis | |
| 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Pseudomonas aeruginosa | |
| 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Staphylococcus aureus | |
| 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Streptococcus pneumoniae | |
| 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Enterobacter cloacae | |
| 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Escherichia coli | |
| 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Mycobacterium tuberculosis | |
| 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Pseudomonas aeruginosa | |
| 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Staphylococcus aureus | |
| 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Streptococcus pneumoniae | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Enterobacter cloacae | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Mycobacterium tuberculosis | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Pseudomonas aeruginosa | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Streptococcus pneumoniae | |
| 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Enterobacter cloacae | |
| 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
| 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Mycobacterium tuberculosis | |
| 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Pseudomonas aeruginosa | |
| 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
| 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Streptococcus pneumoniae | |
| 5-bromo-2-oxo-1,3-benzoxathiol-6-yl phenyl carbonate | - |
Enterobacter cloacae | |
| 5-bromo-2-oxo-1,3-benzoxathiol-6-yl phenyl carbonate | - |
Escherichia coli | |
| 5-bromo-2-oxo-1,3-benzoxathiol-6-yl phenyl carbonate | - |
Mycobacterium tuberculosis | |
| 5-bromo-2-oxo-1,3-benzoxathiol-6-yl phenyl carbonate | - |
Pseudomonas aeruginosa | |
| 5-bromo-2-oxo-1,3-benzoxathiol-6-yl phenyl carbonate | - |
Staphylococcus aureus | |
| 5-bromo-2-oxo-1,3-benzoxathiol-6-yl phenyl carbonate | - |
Streptococcus pneumoniae | |
| 5-hydroxy-1,3-benzoxathiol-2-one | - |
Enterobacter cloacae | |
| 5-hydroxy-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
| 5-hydroxy-1,3-benzoxathiol-2-one | - |
Mycobacterium tuberculosis | |
| 5-hydroxy-1,3-benzoxathiol-2-one | - |
Pseudomonas aeruginosa | |
| 5-hydroxy-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
| 5-hydroxy-1,3-benzoxathiol-2-one | - |
Streptococcus pneumoniae | |
| 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Enterobacter cloacae | |
| 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
| 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Mycobacterium tuberculosis | |
| 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Pseudomonas aeruginosa | |
| 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
| 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Streptococcus pneumoniae | |
| 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Enterobacter cloacae | |
| 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Escherichia coli | |
| 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Mycobacterium tuberculosis | |
| 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Pseudomonas aeruginosa | |
| 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Staphylococcus aureus | |
| 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Streptococcus pneumoniae | |
| cnicine | - |
Enterobacter cloacae | |
| cnicine | - |
Escherichia coli | |
| cnicine | - |
Mycobacterium tuberculosis | |
| cnicine | - |
Pseudomonas aeruginosa | |
| cnicine | - |
Staphylococcus aureus | |
| cnicine | - |
Streptococcus pneumoniae | |
| cynaropicrin | - |
Enterobacter cloacae | |
| cynaropicrin | - |
Escherichia coli | |
| cynaropicrin | - |
Mycobacterium tuberculosis | |
| cynaropicrin | - |
Pseudomonas aeruginosa | |
| cynaropicrin | - |
Staphylococcus aureus | |
| cynaropicrin | - |
Streptococcus pneumoniae | |
| diarylmethane | - |
Enterobacter cloacae | |
| diarylmethane | - |
Escherichia coli | |
| diarylmethane | - |
Mycobacterium tuberculosis | |
| diarylmethane | - |
Pseudomonas aeruginosa | |
| diarylmethane | - |
Staphylococcus aureus | |
| diarylmethane | - |
Streptococcus pneumoniae | |
| ebselen | - |
Enterobacter cloacae | |
| ebselen | - |
Escherichia coli | |
| ebselen | - |
Mycobacterium tuberculosis | |
| ebselen | - |
Pseudomonas aeruginosa | |
| ebselen | - |
Staphylococcus aureus | |
| ebselen | - |
Streptococcus pneumoniae | |
| fosfomycin | irreversible inhibitor | Enterobacter cloacae | |
| fosfomycin | irreversible inhibitor | Escherichia coli | |
| fosfomycin | irreversible inhibitor | Mycobacterium tuberculosis | |
| fosfomycin | irreversible inhibitor | Pseudomonas aeruginosa | |
| fosfomycin | irreversible inhibitor | Staphylococcus aureus | |
| fosfomycin | irreversible inhibitor | Streptococcus pneumoniae | |
| HESFWYLPHHQSY | competitive inhibition | Enterobacter cloacae | |
| HESFWYLPHHQSY | competitive inhibition | Escherichia coli | |
| HESFWYLPHHQSY | competitive inhibition | Mycobacterium tuberculosis | |
| HESFWYLPHHQSY | competitive inhibition | Pseudomonas aeruginosa | |
| HESFWYLPHHQSY | competitive inhibition | Staphylococcus aureus | |
| HESFWYLPHHQSY | competitive inhibition | Streptococcus pneumoniae | |
| imidazole | - |
Enterobacter cloacae | |
| imidazole | - |
Escherichia coli | |
| imidazole | - |
Mycobacterium tuberculosis | |
| imidazole | - |
Pseudomonas aeruginosa | |
| imidazole | - |
Staphylococcus aureus | |
| imidazole | - |
Streptococcus pneumoniae | |
| pyrazolopyrimidine | reversible inhibitor | Enterobacter cloacae | |
| pyrazolopyrimidine | reversible inhibitor | Escherichia coli | |
| pyrazolopyrimidine | reversible inhibitor | Mycobacterium tuberculosis | |
| pyrazolopyrimidine | reversible inhibitor | Pseudomonas aeruginosa | |
| pyrazolopyrimidine | reversible inhibitor | Staphylococcus aureus | |
| pyrazolopyrimidine | reversible inhibitor | Streptococcus pneumoniae | |
| RWJ-110192 | reversible inhibitor | Enterobacter cloacae | |
| RWJ-110192 | reversible inhibitor | Escherichia coli | |
| RWJ-110192 | reversible inhibitor | Mycobacterium tuberculosis | |
| RWJ-110192 | reversible inhibitor | Pseudomonas aeruginosa | |
| RWJ-110192 | reversible inhibitor | Staphylococcus aureus | |
| RWJ-110192 | reversible inhibitor | Streptococcus pneumoniae | |
| RWJ-140998 | irreversible inhibitor | Enterobacter cloacae | |
| RWJ-140998 | irreversible inhibitor | Escherichia coli | |
| RWJ-140998 | irreversible inhibitor | Mycobacterium tuberculosis | |
| RWJ-140998 | irreversible inhibitor | Pseudomonas aeruginosa | |
| RWJ-140998 | irreversible inhibitor | Staphylococcus aureus | |
| RWJ-140998 | irreversible inhibitor | Streptococcus pneumoniae | |
| RWJ-3981 | irreversible inhibitor | Enterobacter cloacae | |
| RWJ-3981 | irreversible inhibitor | Escherichia coli | |
| RWJ-3981 | irreversible inhibitor | Mycobacterium tuberculosis | |
| RWJ-3981 | irreversible inhibitor | Pseudomonas aeruginosa | |
| RWJ-3981 | irreversible inhibitor | Staphylococcus aureus | |
| RWJ-3981 | irreversible inhibitor | Streptococcus pneumoniae | |
| T6361 | competitive inhibition | Enterobacter cloacae | |
| T6361 | competitive inhibition | Escherichia coli | |
| T6361 | competitive inhibition | Mycobacterium tuberculosis | |
| T6361 | competitive inhibition | Pseudomonas aeruginosa | |
| T6361 | competitive inhibition | Staphylococcus aureus | |
| T6361 | competitive inhibition | Streptococcus pneumoniae | |
| T6362 | competitive inhibition | Enterobacter cloacae | |
| T6362 | competitive inhibition | Escherichia coli | |
| T6362 | competitive inhibition | Mycobacterium tuberculosis | |
| T6362 | competitive inhibition | Pseudomonas aeruginosa | |
| T6362 | competitive inhibition | Staphylococcus aureus | |
| T6362 | competitive inhibition | Streptococcus pneumoniae | |
| terreic acid | irreversible inhibitor | Enterobacter cloacae | |
| terreic acid | irreversible inhibitor | Escherichia coli | |
| terreic acid | irreversible inhibitor | Mycobacterium tuberculosis | |
| terreic acid | irreversible inhibitor | Pseudomonas aeruginosa | |
| terreic acid | irreversible inhibitor | Staphylococcus aureus | |
| terreic acid | irreversible inhibitor | Streptococcus pneumoniae | |
| thimerosal | - |
Enterobacter cloacae | |
| thimerosal | - |
Escherichia coli | |
| thimerosal | - |
Mycobacterium tuberculosis | |
| thimerosal | - |
Pseudomonas aeruginosa | |
| thimerosal | - |
Staphylococcus aureus | |
| thimerosal | - |
Streptococcus pneumoniae | |
| thiram | - |
Enterobacter cloacae | |
| thiram | - |
Escherichia coli | |
| thiram | - |
Mycobacterium tuberculosis | |
| thiram | - |
Pseudomonas aeruginosa | |
| thiram | - |
Staphylococcus aureus | |
| thiram | - |
Streptococcus pneumoniae | |
| tulipaline A | - |
Enterobacter cloacae | |
| tulipaline A | - |
Escherichia coli | |
| tulipaline A | - |
Mycobacterium tuberculosis | |
| tulipaline A | - |
Pseudomonas aeruginosa | |
| tulipaline A | - |
Staphylococcus aureus | |
| tulipaline A | - |
Streptococcus pneumoniae | |
| tulipaline B | - |
Enterobacter cloacae | |
| tulipaline B | - |
Escherichia coli | |
| tulipaline B | - |
Mycobacterium tuberculosis | |
| tulipaline B | - |
Pseudomonas aeruginosa | |
| tulipaline B | - |
Staphylococcus aureus | |
| tulipaline B | - |
Streptococcus pneumoniae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00045 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 0.004 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Escherichia coli | |
| 0.0083 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Enterobacter cloacae | |
| 0.01148 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Staphylococcus aureus | |
| 0.015 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Escherichia coli | |
| 0.0178 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 0.037 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Streptococcus pneumoniae | |
| 0.08 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Enterobacter cloacae | |
| 0.1239 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Staphylococcus aureus | |
| 0.244 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Streptococcus pneumoniae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterobacter cloacae | P33038 | - |
- |
| Escherichia coli | P0A749 | - |
- |
| Mycobacterium tuberculosis | P9WJM1 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WJM1 | - |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Staphylococcus aureus | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Pseudomonas aeruginosa | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Streptococcus pneumoniae | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Escherichia coli | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Enterobacter cloacae | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Mycobacterium tuberculosis | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Mycobacterium tuberculosis H37Rv | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MurA | - |
Staphylococcus aureus |
| MurA | - |
Pseudomonas aeruginosa |
| MurA | - |
Streptococcus pneumoniae |
| MurA | - |
Escherichia coli |
| MurA | - |
Enterobacter cloacae |
| MurA | - |
Mycobacterium tuberculosis |
| UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Staphylococcus aureus |
| UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Pseudomonas aeruginosa |
| UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Streptococcus pneumoniae |
| UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Escherichia coli |
| UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Enterobacter cloacae |
| UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Mycobacterium tuberculosis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.41 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Streptococcus pneumoniae | |
| 0.41 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Streptococcus pneumoniae | |
| 1.13 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Staphylococcus aureus | |
| 1.13 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Staphylococcus aureus | |
| 1.8 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 1.8 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 3 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Enterobacter cloacae | |
| 3 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Enterobacter cloacae | |
| 3.8 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Escherichia coli | |
| 3.8 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme catalyzes the first committed step in the biosynthesis of peptidoglycan, an integral and essential component of the bacterial cell wall | Staphylococcus aureus |
| physiological function | the enzyme catalyzes the first committed step in the biosynthesis of peptidoglycan, an integral and essential component of the bacterial cell wall | Pseudomonas aeruginosa |
| physiological function | the enzyme catalyzes the first committed step in the biosynthesis of peptidoglycan, an integral and essential component of the bacterial cell wall | Streptococcus pneumoniae |
| physiological function | the enzyme catalyzes the first committed step in the biosynthesis of peptidoglycan, an integral and essential component of the bacterial cell wall | Escherichia coli |
| physiological function | the enzyme catalyzes the first committed step in the biosynthesis of peptidoglycan, an integral and essential component of the bacterial cell wall | Enterobacter cloacae |
| physiological function | the enzyme catalyzes the first committed step in the biosynthesis of peptidoglycan, an integral and essential component of the bacterial cell wall | Mycobacterium tuberculosis |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000017 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Streptococcus pneumoniae | |
| 0.000005 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Staphylococcus aureus | |
| 0.000009 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Staphylococcus aureus | |
| 0.000011 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Streptococcus pneumoniae | |
| 0.0000375 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Enterobacter cloacae | |
| 0.000101 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 0.00025 | - |
UDP-N-acetyl-D-glucosamine | pH and temperature not specified in the publication | Escherichia coli | |
| 0.00036 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Enterobacter cloacae | |
| 0.004 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 0.01 | - |
phosphoenolpyruvate | pH and temperature not specified in the publication | Escherichia coli | |
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