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Literature summary for 2.5.1.18 extracted from

  • Bartley, K.; Wright, H.W.; Bull, R.S.; Huntley, J.F.; Nisbet, A.J.
    Characterisation of Dermanyssus gallinae glutathione S-transferases and their potential as acaricide detoxification proteins (2015), Parasit. Vectors, 8, 350.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells Dermanyssus gallinae

Inhibitors

Inhibitors Comment Organism Structure
4-nitrobenzyl chloride 50.8% inhibition of isoform GST-1 at 1 mM, 18.1% inhibition of isoform GST-2 at 1 mM, 33.3% inhibition of isoform GST-3 at 1 mM Dermanyssus gallinae
abamectin 17% inhibition of isoform GST-1 at 0.1 mM Dermanyssus gallinae
additional information isoforms GST-2 and GST-3 are not inhibited by permethrin and abamectin. Isoforms GST-1, GST-2, and GST3 are not inhibited by spinosad Dermanyssus gallinae
permethrin 35% inhibition of isoform GST-1 at 0.1 mM Dermanyssus gallinae
phoxim 56% inhibition of isoform GST-1 at 0.1 mM, 14.8% inhibition of isoform GST-2 at 0.1 mM, 20.6% inhibition of isoform GST-3 at 0.1 mM Dermanyssus gallinae

Organism

Organism UniProt Comment Textmining
Dermanyssus gallinae
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 poultry red mite
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Purification (Commentary)

Purification (Comment) Organism
affinity column chromatography Dermanyssus gallinae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-chloro-2,4-dinitrobenzene + glutathione isoform GST-1 is 18.3times more active than GST-2 and 26.8times more active than GST-3 Dermanyssus gallinae S-(2,4-dinitrophenyl)glutathione + HCl
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Synonyms

Synonyms Comment Organism
glutathione S-transferase
-
 Dermanyssus gallinae
GST-1 isoform Dermanyssus gallinae
GST-2 isoform Dermanyssus gallinae
GST-3 isoform Dermanyssus gallinae

General Information

General Information Comment Organism
metabolism the enzyme isoforms play important roles in the detoxification of pesticides Dermanyssus gallinae