Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes GSTA1-1, GSTM1-1, and GSTP1-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | GSTM1-1 is a major liver GST, but 50% of the population are hGSTM1-null | Homo sapiens | - |
liver cancer cell | GSTP1-1 is overexpressed in liver cancer cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GSTM1-1 | - |
Homo sapiens |
GSTP1-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | glutathione transferase classes alpha, pi, and mu and their GSH activation mechanism, overview | Homo sapiens |
additional information | structure of G-site active center amino acids of GSTM1-1, GSTP1-1, and GSTA1-1, mechanism comparison of isozymes, overview. Analysis of the GSH activation mechanism of GSTP1-1 and GSTM1-1 isoenzymes, overview. For the GSTP1-1 enzyme, a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol and the GSH glutamate alpha carboxylate groups. The GSTM1-1 enzyme shows a completely different behavior from isoenzyme GSTP1-1, here two water molecules, positioned between the GSH-SH and the zeta N atom of His107, working like a bridge, are able to promote the proton transfer between these two active groups | Homo sapiens |