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Literature summary for 2.5.1.18 extracted from
- Hepatic and branchial glutathione S-transferases of two fish species: substrate specificity and biotransformation of microcystin-LR (2009), Comp. Biochem. Physiol. C, 149, 515-523.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Hypophthalmichthys molitrix | 5829 | - |
| cytosol | - |
Rutilus rutilus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hypophthalmichthys molitrix | - |
- |
- |
| Rutilus rutilus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme by glutathione affinity and anion exchange chromatography | Hypophthalmichthys molitrix |
| native enzyme by glutathione affinity and anion exchange chromatography | Rutilus rutilus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gill | pi and/or alpha class GSTs are the dominant GST classes in gills | Hypophthalmichthys molitrix | - |
| gill | pi and/or alpha class GSTs are the dominant GST classes in gills | Rutilus rutilus | - |
| liver | pi and/or alpha class GSTs are the dominant GST classes in liver | Hypophthalmichthys molitrix | - |
| liver | pi and/or alpha class GSTs are the dominant GST classes in liver | Rutilus rutilus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
substrate specificity of liver and gill enzymes, overview | Hypophthalmichthys molitrix |
| additional information | - |
substrate specificity of liver and gill enzymes, overview | Rutilus rutilus |
| 0.13 | - |
substrate 1-chloro-2,4-dinitrobenzene, gill enzyme | Hypophthalmichthys molitrix |
| 0.27 | - |
substrate 1-chloro-2,4-dinitrobenzene, gill enzyme | Rutilus rutilus |
| 0.36 | - |
substrate 1-chloro-2,4-dinitrobenzene, liver enzyme | Hypophthalmichthys molitrix |
| 0.74 | - |
substrate 1-chloro-2,4-dinitrobenzene, liver enzyme | Rutilus rutilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1,2-dichloro-4-nitrobenzene | substrate of the liver enzyme, no activity by the gill enzyme | Hypophthalmichthys molitrix | ? | - |
? |  |
| glutathione + 1,2-dichloro-4-nitrobenzene | substrate of the liver enzyme, no activity by the gill enzyme | Rutilus rutilus | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Hypophthalmichthys molitrix | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rutilus rutilus | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 4-nitrobenzyl chloride | - |
Hypophthalmichthys molitrix | S-(4-nitrobenzyl)glutathione + HCl | - |
? | |
| glutathione + 4-nitrobenzyl chloride | - |
Rutilus rutilus | S-(4-nitrobenzyl)glutathione + HCl | - |
? | |
| glutathione + ethacrynic acid | - |
Hypophthalmichthys molitrix | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Rutilus rutilus | ? | - |
? | |
| glutathione + microcystin-LR | - |
Hypophthalmichthys molitrix | ? | - |
? | |
| glutathione + microcystin-LR | - |
Rutilus rutilus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione S-transferase | - |
Hypophthalmichthys molitrix |
| glutathione S-transferase | - |
Rutilus rutilus |
| GST | - |
Hypophthalmichthys molitrix |
| GST | - |
Rutilus rutilus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at | Hypophthalmichthys molitrix |
| 28 | - |
assay at | Rutilus rutilus |
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Release 2023.1 (January 2023)
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