Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)imidazole | - |
Homo sapiens | |
3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid | - |
Homo sapiens | |
4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol | - |
Homo sapiens | |
6-(7-nitro-2,1,3-benzoxadiazol-4-ylamino)hexanol | - |
Homo sapiens | |
6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol | - |
Homo sapiens | |
7-nitro-2,1,3-benzoxadiazole derivatives | non-GSH peptidomimetic compounds, suicide inhibitors of the enzyme, binding structure and mechanism, overview, the compounds show strong GST inhibition and accumulation in tumor cells avoiding the extrusion mechanisms mediated by the multidrug resistance protein pumps | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | stopped flow rapid kinetics, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes GSTA1-1, GSTM2-2, and GSTP1-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GLC-4 cell | a small cell lung carcinoma cell line | Homo sapiens | - |
Hep-G2 cell | a hepatic carcinoma cell line | Homo sapiens | - |
K-562 cell | a myeloid leukemia cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
glutathione S-transferase | - |
Homo sapiens |
GST | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
pH 6.5, 25°C, recombinant isoyzme GSTP1-1 | Homo sapiens | 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol | |
0.00001 | - |
pH 6.5, 25°C, recombinant isoyzme GSTP1-1 | Homo sapiens | 2-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)imidazole | |
0.00003 | - |
pH 6.5, 25°C, recombinant isoyzme GSTP1-1 | Homo sapiens | 4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol | |
0.0003 | - |
pH 6.5, 25°C, recombinant isoyzme GSTP1-1 | Homo sapiens | 3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid | |
0.0008 | - |
pH 6.5, 25°C, recombinant isoyzme GSTM2-2 | Homo sapiens | 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol | |
0.0018 | - |
pH 6.5, 25°C, recombinant isoyzme GSTP1-1 | Homo sapiens | 6-(7-nitro-2,1,3-benzoxadiazol-4-ylamino)hexanol | |
0.002 | - |
pH 6.5, 25°C, recombinant isoyzme GSTM2-2 | Homo sapiens | 4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol | |
0.0057 | - |
pH 6.5, 25°C, recombinant isoyzme GSTM2-2 | Homo sapiens | 3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid | |
0.0063 | - |
pH 6.5, 25°C, recombinant isoyzme GSTM2-2 | Homo sapiens | 2-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)imidazole | |
0.011 | - |
pH 6.5, 25°C, recombinant isoyzme GSTA1-1 | Homo sapiens | 2-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)imidazole | |
0.025 | - |
pH 6.5, 25°C, recombinant isoyzme GSTA1-1 | Homo sapiens | 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol | |
0.056 | - |
pH 6.5, 25°C, recombinant isoyzme GSTA1-1 | Homo sapiens | 4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol | |
0.066 | - |
pH 6.5, 25°C, recombinant isoyzme GSTA1-1 | Homo sapiens | 3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid | |
0.1 | - |
above, pH 6.5, 25°C, recombinant isoyzme GSTA1-1 | Homo sapiens | 6-(7-nitro-2,1,3-benzoxadiazol-4-ylamino)hexanol | |
0.1 | - |
above, pH 6.5, 25°C, recombinant isoyzme GSTM2-2 | Homo sapiens | 6-(7-nitro-2,1,3-benzoxadiazol-4-ylamino)hexanol |