Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-gamma-glutamyl-S-(2-hydroxy-5-nitrophenyl)-L-cysteinylglycine | nonenzymatically synthesized GSH conjugate | Schistosoma japonicum | |
L-gamma-glutamyl-S-[(17beta)-17-hydroxy-17-methyl-3-oxoandrost-4-en-4-yl]-L-cysteinylglycine | nonenzymatically synthesized GSH conjugate | Schistosoma japonicum | |
L-gamma-glutamyl-S-[1-(3-chlorophenyl)-2-hydroxyethyl]-L-cysteinylglycine | nonenzymatically synthesized GSH conjugate | Schistosoma japonicum | |
L-gamma-glutamyl-S-[2-(4-nitrophenyl)-2-oxoethyl]-L-cysteinylglycine | nonenzymatically synthesized GSH conjugate | Schistosoma japonicum | |
L-gamma-glutamyl-S-[2-(6-oxocyclohex-1-en-1-yl)ethyl]-L-cysteinylglycine | nonenzymatically synthesized GSH conjugate | Schistosoma japonicum | |
L-gamma-glutamyl-S-[3-[4-(carboxymethoxy)-2,3-dichlorophenyl]-3-oxopropyl]-L-cysteinylglycine | nonenzymatically synthesized GSH conjugate | Schistosoma japonicum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of formation of specific mono(glutathionyl) or bis(glutathionyl) conjugates | Schistosoma japonicum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Schistosoma japonicum | a primary pathway for metabolism of electrophilic compounds in Schistosoma japonicum involves glutathione S-transferase-catalyzed formation of glutathione conjugates, overview, production of nonenzymatic GSH conjugates with electrophilic substrates often overwhelms the activity of the enzyme, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma japonicum | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
RX + glutathione = HX + R-S-glutathione | mechanisms for formation of specific mono(glutathionyl) or bis(glutathionyl) conjugates | Schistosoma japonicum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,3,5-triacryloyl-1,3,5-triazinane + glutathione | - |
Schistosoma japonicum | L-gamma-glutamyl-S-[3-(3,5-diacryloyl-1,3,5-triazinan-1-yl)-3-oxopropyl]-L-cysteinylglycine | - |
? | |
1-chloro-2,4-dinitrobenzene + glutathione | - |
Schistosoma japonicum | chloride + L-gamma-glutamyl-S-(2,4-dinitrophenyl)-L-cysteinylglycine | - |
? | |
2-chloro-5-nitropyridine + glutathione | - |
Schistosoma japonicum | chloride + L-gamma-glutamyl-S-(5-nitropyridin-2-yl)-L-cysteinylglycine | - |
? | |
7-oxabicyclo[4.1.0]heptan-2-one + glutathione | - |
Schistosoma japonicum | chloride + L-gamma-glutamyl-S-(6-oxocyclohex-1-en-1-yl)-L-cysteinylglycine | - |
? | |
methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate + glutathione | - |
Schistosoma japonicum | chloride + L-gamma-glutamyl-S-[2-hydroxy-3-methoxy-1-(4-methoxyphenyl)-3-oxopropyl]-L-cysteinylglycine | - |
? | |
additional information | a primary pathway for metabolism of electrophilic compounds in Schistosoma japonicum involves glutathione S-transferase-catalyzed formation of glutathione conjugates, overview, production of nonenzymatic GSH conjugates with electrophilic substrates often overwhelms the activity of the enzyme, overview | Schistosoma japonicum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione S-transferase | - |
Schistosoma japonicum |
GST | - |
Schistosoma japonicum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Schistosoma japonicum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.037 | - |
7-oxabicyclo[4.1.0]heptan-2-one | 4°C, 20 mM sodium phosphate buffer, pH 6.5, 0.5 mM glutathione | Schistosoma japonicum | |
0.044 | - |
2-chloro-5-nitropyridine | 25°C, 20 mM sodium phosphate buffer, pH 7.0, 0.5 mM glutathione | Schistosoma japonicum | |
0.63 | - |
methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate | 25°C, 20 mM sodium phosphate buffer, pH 7.0, 0.5 mM glutathione | Schistosoma japonicum | |
39 | - |
L-gamma-glutamyl-S-[2-hydroxy-3-methoxy-1-(4-methoxyphenyl)-3-oxopropyl]-L-cysteinylglycine | 25°C, 20 mM sodium phosphate buffer, pH 7.0, 0.5 mM glutathione | Schistosoma japonicum | |
187 | - |
1-chloro-2,4-dinitrobenzene | 4°C, 20 mM sodium phosphate buffer, pH 6.5, 0.5 mM glutathione | Schistosoma japonicum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Schistosoma japonicum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000036 | - |
- |
Schistosoma japonicum | L-gamma-glutamyl-S-[3-[4-(carboxymethoxy)-2,3-dichlorophenyl]-3-oxopropyl]-L-cysteinylglycine | |
0.00096 | - |
- |
Schistosoma japonicum | L-gamma-glutamyl-S-[1-(3-chlorophenyl)-2-hydroxyethyl]-L-cysteinylglycine | |
0.00195 | - |
- |
Schistosoma japonicum | L-gamma-glutamyl-S-(2-hydroxy-5-nitrophenyl)-L-cysteinylglycine | |
0.019 | - |
- |
Schistosoma japonicum | L-gamma-glutamyl-S-[(17beta)-17-hydroxy-17-methyl-3-oxoandrost-4-en-4-yl]-L-cysteinylglycine | |
0.0755 | - |
- |
Schistosoma japonicum | L-gamma-glutamyl-S-[2-(4-nitrophenyl)-2-oxoethyl]-L-cysteinylglycine | |
0.152 | - |
- |
Schistosoma japonicum | L-gamma-glutamyl-S-[2-(6-oxocyclohex-1-en-1-yl)ethyl]-L-cysteinylglycine |