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Literature summary for 2.5.1.18 extracted from
- Purification and characterization of a new form of glutathione S-transferase from human erythrocytes (1984), Biochem. Biophys. Res. Commun., 125, 1053-1060.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromosulfophthalein | inhibits only minor form, but not major form | Homo sapiens |  |
| Hematin | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens | |
| 0.5 | - |
glutathione | major form | Homo sapiens | |
| 0.6 | - |
1-chloro-2,4-dinitrobenzene | major form | Homo sapiens | |
| 1.9 | - |
1-chloro-2,4-dinitrobenzene | minor form | Homo sapiens | |
| 2 | - |
glutathione | minor form | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
erythrocytes, minor form | Homo sapiens |
| 47000 | - |
erythrocytes, major form | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1-chloro-2,4-dinitrobenzene | enzyme has only weak activity towards the substrate | Homo sapiens | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
| glutathione + 4-nitrobenzyl chloride | - |
Homo sapiens | ? | - |
? | |
| glutathione + bromosulfophthalein | - |
Homo sapiens | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Homo sapiens | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Homo sapiens | ? | - |
? | |
| additional information | specificity | Homo sapiens | ? | - |
? | |
| RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Homo sapiens | HX + R-S-glutathione | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.5 | - |
1-chloro-2,4-dinitrobenzene | minor enzyme form | Homo sapiens | |
| 7.67 | - |
glutathione | minor enzyme form | Homo sapiens | |
| 12.2 | - |
glutathione | major enzyme form | Homo sapiens | |
| 18.3 | - |
1-chloro-2,4-dinitrobenzene | major enzyme form | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
Hematin | major form | Homo sapiens | |
| 0.032 | - |
Hematin | minor form | Homo sapiens | |
| 0.068 | - |
bromosulfophthalein | minor form | Homo sapiens | |
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