Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bromosulfophthalein | - |
Rattus norvegicus | |
Cibacron blue | - |
Rattus norvegicus | |
Hematin | - |
Rattus norvegicus | |
indomethacin | - |
Rattus norvegicus | |
Rose bengal | - |
Rattus norvegicus | |
S-(4-Bromobenzyl)glutathione | - |
Rattus norvegicus | |
sulfophthalein | - |
Rattus norvegicus | |
Tributyltin acetate | - |
Rattus norvegicus | |
Triethyltin bromide | - |
Rattus norvegicus | |
Triphenyltin chloride | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RX + glutathione | Rattus norvegicus | detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides | HX + R-S-glutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male specific-pathogen-free Sprague Dawley | - |
Purification (Comment) | Organism |
---|---|
7 major isoenzymes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
16.7 | 64.1 | with 1-chloro-2,4-dinitrobenzene as substrate | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1,2-dichloro-4-nitrobenzene | - |
Rattus norvegicus | ? | - |
? | |
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane | - |
Rattus norvegicus | ? | - |
? | |
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
glutathione + 4-nitrophenyl acetate | - |
Rattus norvegicus | ? | - |
? | |
glutathione + androst-5-ene-3,17-dione | - |
Rattus norvegicus | ? | - |
? | |
glutathione + cumene hydroperoxide | - |
Rattus norvegicus | ? | - |
? | |
glutathione + ethacrynic acid | - |
Rattus norvegicus | ? | - |
? | |
glutathione + trans-4-phenyl-3-buten-2-one | - |
Rattus norvegicus | ? | - |
? | |
additional information | specificity | Rattus norvegicus | ? | - |
? | |
RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Rattus norvegicus | HX + R-S-glutathione | - |
? | |
RX + glutathione | detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides | Rattus norvegicus | HX + R-S-glutathione | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
27 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 4-4, cofactor: glutathione | Rattus norvegicus | |
54 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 3-3, cofactor: glutathione | Rattus norvegicus | |
63 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 1-2, cofactor: glutathione | Rattus norvegicus | |
65 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 3-4, cofactor: glutathione | Rattus norvegicus | |
78 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 1-1, cofactor: glutathione | Rattus norvegicus | |
82 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 3-?, cofactor: glutathione | Rattus norvegicus |