Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.18 extracted from

  • Alin, P.; Jensson, H.; Guthenberg, C.; Danielson, U.H.; Tahir, M.K.; Mannervik, B.
    Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing (1985), Anal. Biochem., 146, 313-320.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bromosulfophthalein
-
Rattus norvegicus
Cibacron blue
-
Rattus norvegicus
Hematin
-
Rattus norvegicus
indomethacin
-
Rattus norvegicus
Rose bengal
-
Rattus norvegicus
S-(4-Bromobenzyl)glutathione
-
Rattus norvegicus
sulfophthalein
-
Rattus norvegicus
Tributyltin acetate
-
Rattus norvegicus
Triethyltin bromide
-
Rattus norvegicus
Triphenyltin chloride
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RX + glutathione Rattus norvegicus detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides HX + R-S-glutathione
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male specific-pathogen-free Sprague Dawley
-

Purification (Commentary)

Purification (Comment) Organism
7 major isoenzymes Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
16.7 64.1 with 1-chloro-2,4-dinitrobenzene as substrate Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1,2-dichloro-4-nitrobenzene
-
Rattus norvegicus ?
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
-
Rattus norvegicus ?
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
-
Rattus norvegicus S-2,4-dinitrophenylglutathione + HCl
-
?
glutathione + 4-nitrophenyl acetate
-
Rattus norvegicus ?
-
?
glutathione + androst-5-ene-3,17-dione
-
Rattus norvegicus ?
-
?
glutathione + cumene hydroperoxide
-
Rattus norvegicus ?
-
?
glutathione + ethacrynic acid
-
Rattus norvegicus ?
-
?
glutathione + trans-4-phenyl-3-buten-2-one
-
Rattus norvegicus ?
-
?
additional information specificity Rattus norvegicus ?
-
?
RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Rattus norvegicus HX + R-S-glutathione
-
?
RX + glutathione detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides Rattus norvegicus HX + R-S-glutathione
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
27
-
1-chloro-2,4-dinitrobenzene isoenzyme 4-4, cofactor: glutathione Rattus norvegicus
54
-
1-chloro-2,4-dinitrobenzene isoenzyme 3-3, cofactor: glutathione Rattus norvegicus
63
-
1-chloro-2,4-dinitrobenzene isoenzyme 1-2, cofactor: glutathione Rattus norvegicus
65
-
1-chloro-2,4-dinitrobenzene isoenzyme 3-4, cofactor: glutathione Rattus norvegicus
78
-
1-chloro-2,4-dinitrobenzene isoenzyme 1-1, cofactor: glutathione Rattus norvegicus
82
-
1-chloro-2,4-dinitrobenzene isoenzyme 3-?, cofactor: glutathione Rattus norvegicus